Publications and Patents

VTCDD Member Publications

Josep Bassaganya-Riera

Auer, K.; Trachter, R.; Van den Bogaerde, J.; Bassaganya-Riera, J.; Sorrentino, D. Translational research and efficacy of biologics in Crohn’s disease: a cautionary tale. Expert Rev Clin Immunol. 2014,10, 219–229.

Lemkul, J.; Lewis, S.; Bassaganya-Riera, J.; Bevan, D. Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.PlosOne. 2015;In Press.

Carbo, A.; Hontecillas, R.; Viladomiu, M.; Leber, A.; Hoops, S.; Bassaganya-Riera, J. Modeling the Dynamics of T Helper 17 Induction and Differentiation. MOJ Immunol20152.

Leber, A.; Viladomiu, M.; Hontecillas, R.; Abedi, V.; Philipson, C.; Hoops, S.; Howard, B.; Bassaganya-Riera, J.. Systems modeling of interactions between mucosal immunity and the gut microbiome during Clostridium difficile infection. Plos One2015;In Press.

Lewis, S.N.; Garcia, Z.; Hontecillas, R.; Bassaganya-Riera, J.; Bevan, D.R. Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands. J Comput Aided Mol Des.2015.

Matthew W. Buczynski

  1. Buczynski MW#, Niessen S#, Dix MM, Polis IY, Natividad LA, Sidhpura N, Cravatt BF, Parsons LH. PROTOMAP proteomics reveals that chronic nicotine exposure increases amygdalar PDE10A to facilitate affective behavior. (2016), in preparation.
  2. Serrano A, Buczynski MW, Schlosburg JE, Pavon FJ, Polis IY, Stouffer D, , Zorrilla EP, Cravatt BF, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol self-administration. (2016), in preparation.
  3. Irimia C, Buczynski MW, Laredo SA, Avalos N, Parsons LH. Dysregulated signaling in the infralimbic cortex contributes to increased impulsivity during protracted alcohol abstinence. (2016), in submission.
  4. Buczynski MW#, Herman MA#, Hsu KL#, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Parsons LH. Chronic nicotine exposure diminishes inhibitory control of VTA DA neurons through enhanced diacylglycerol lipase-mediated signaling. (2016), PNAS 113, 1086-91.
  5. Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. (2013), PNAS 110, 13961, E2518-27.
  6. Niphakis MJ, Cognetta AB, Chang JW, Buczynski MW, Byrne F, Burston JJ, Chapman V, Cravatt BF. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. (2013), ACS Chem Neurosci 4,1322-32.
  7. Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. (2013) FASEB 27, 1939-49.
  8. Buczynski MW, Polis IY, Parsons LH. The volitional nature of nicotine exposure differentially alters anandamide and oleoylethanolamide levels in the ventral tegmental area. (2013) Neuropsychopharmacology 38, 574-84.
Paul R. Carlier  

Yao, Z.-K.; Krai, P. M.; Merino, E. F.; Simpson, M. E.; Slebodnick, C.; Cassera, M. B.; Carlier, P. R. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorganic & Medicinal Chemistry Letters 2015,25, 0000.

Verma, A.; Wong, D. M.; Islam, R.; Tong, F.; Ghavami, M.; Mutunga, J. M.; Slebodnick, C.; Li, J.; Viayna, E.; Lam, P. C. H.; Totrov, M. M.; Bloomquist, J. R.; Carlier, P. R. 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae Bioorganic & Medicinal Chemistry 2015, 23, 1321-1340.  doi:10.1016/j.bmc.2015.01.026

Hu, S.; Wang, R.; Cui, W.; Zhang, Z.; Mak, S.; Xu, D.; Choi, C.; Tsim, K. W.-k.; Carlier, P. R.; Han, Y.-F. Inhibiting beta-amyloid-associated Alzheimer’s pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analog. Journal of Molecular Neuroscience 2015, 55, 1014-1015. PMID: 25407821

Bowman, J. D.; Merino, E. F.; Brooks, C. F.; Striepen, B.; Carlier, P. R.; Cassera, M. B. Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box. Antimicrobial Agents and Chemotherapy 2014, 58, 811-819. PMCID: PMC3910863

Monceaux, C. J.; Hirata-Fukae, C.; Lam, P. C. H.; Totrov, M. M.; Matsuoka, Y.; Carlier, P. R. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer’s BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters 2011,21, 3992-3996.  PMID: 21621412

Blaise M. Costa

Costa, B. M.; Feng, B.; Tsintsadze, T. S.; Morley, R. M.; Irvine, M. W.; Tsintsadze, V.; Lozovaya, N. A.; Jane, D. E.; Monaghan, D. T., N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther 2009331 (2), 618-26.  DOI: 10.1124/jpet.109.156752

Costa, B. M.; Irvine, M. W.; Fang, G.; Eaves, R. J.; Mayo-Martin, M. B.; Laube, B.; Jane, D. E.; Monaghan, D. T., Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology 2012, 62 (4), 1730-6.  DOI: 10.1016/j.neuropharm.2011.11.019

Costa, B. M.; Irvine, M. W.; Fang, G.; Eaves, R. J.; Mayo-Martin, M. B.; Skifter, D. A.; Jane, D. E.; Monaghan, D. T., A novel family of negative and positive allosteric modulators of NMDA receptors. J Pharmacol Exp Ther 2010335 (3), 614-21. DOI: 10.1124/jpet.110.174144 

Irvine, M. W.; Costa, B. M.; Dlaboga, D.; Culley, G. R.; Hulse, R.; Scholefield, C. L.; Atlason, P.; Fang, G.; Eaves, R.; Morley, R.; Mayo-Martin, M. B.; Amici, M.; Bortolotto, Z. A.; Donaldson, L.; Collingridge, G. L.; Molnar, E.; Monaghan, D. T.; Jane, D. E., Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. J Med Chem 2012, 55 (1), 327-41.  DOI: 10.1021/jm201230z

Irvine, M. W.; Costa, B. M.; Volianskis, A.; Fang, G.; Ceolin, L.; Collingridge, G. L.; Monaghan, D. T.; Jane, D. E., Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int 2012, 61(4), 593-600.  DOI:10.1016/j.neuint.2011.12.020

Raphael V. Davalos

Colacino, K. R.; Arena, C. B.; Dong, S.; Roman, M.; Davalos, R.; Lee, Y. W. Folate Conjugated Cellulose Nanocrystals Potentiate Irreversible Electroporation-induced Cytotoxicity for the Selective Treatment of Cancer Cells. Technol. Cancer Res. Treat.  2014, [Epub ahead of print]  PMID: 24750004

Arena, C. B.; Garcia, P. A.; Sano, M. B.; Olson, J. D.; Rogers-Cotrone, T.; Rossmeisl Jr., J. H.; Davalos, R. V. Focal blood-brain-barrier disruption with high-frequency pulsed electric fields. Technology. 2014, 2, 3.  DOI: 10.1142/S2339547814500186

Welsh, J. D.; Charonko, J. J.; Salmanzadeh, A.; Drahos, K. E.; Shafiee, H.; Stremler, M. A.; Davalos, R. V.; Capelluto, D. G.; Vlachos, P. P.; Finkielstein, C. V. Disabled-2 modulates homotypic and heterotypic platelet interactions by binding to sulfatides. Br. J. Haematol.2011154, 122-133.  PMID: 21539534

Salmanzadeh, A.; Elvington, E. S.; Roberts, P. C.; Schmelz, E. M.; Davalos, R. V. Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. Integr. Biol. 2013, 5, 843.  DOI: 10.1039/c3ib00008g

Neal 2nd, R. E.; Rossmeisl Jr., J. H.; D’Alfonso, V.; Robertson, J. L.; Garcia, P. A.; Elankumaran, S.; Davalos, R. V. In vitro and numerical support for combinatorial irreversible electroporation and electrochemotherapy gliomatreatment. Ann. Biomed. Eng. 201442, 475-487. PMID: 24165928

Raffaella De Vita

Guo, Z.; Freeman, J. W.; Barrett, J. B.; De Vita, R. Quantification of Strain Induced Damage in Medial Collateral Ligaments, Journal of Biomechanical Engineering2015137, 1-6.

Tan, T.; De Vita, R.; A Structural Constitutive Model for Smooth Muscle Contraction in Biological TissuesInternational Journal of Non-Linear Mechanics, 2015, 75, 46-53.

Tan, T.; Davis, F.; Gruber, D. D.; Massengill, J. C.; Robertson, J. L.; De Vita, R. Histo-mechanical Properties of Swine Uterosacral and Cardinal Ligaments, Journal of the Mechanical Behavior of Biomedical Materials,2015, 42, 129-137.

Becker, W. R.; De Vita, R. Biaxial Mechanical Properties of Swine Uterosacral and Cardinal Ligaments, Biomechanics and Modeling in Mechanobiology, 201514, 549-560.

Harry C. Dorn

Zhang, J.; Dorn, H.C. NMR Studies of the Dynamics of Encapsulated Ions and Clusters in Fullerene Cages: A Wheel Within a WheelFullerenes, Nanotubes and Carbon Nanostructures201422, 35-46.

Zuo, T.; Dorn, H.C.; Beavers, C.M.; Olmstead, M.M.; Balch, A.L. Isolation and Crystallographic Characterization of Tm3N@D2(35)-C88. Fullerenes, Nanotubes and Carbon Nanostructures201422, 280-288.

Kiselev, B.; Zhang, J.; Dorn, H.C. Biomedical Applications of Trimetalic Nitride Endohedral Metallofullerenes. Endohedral Fullerenes: From Fundamentals to Application, Eds. Yang, S. and Wang, C.-R.  (2014)

Wang, X.; Isley, W.; Salido, S. I.; Tsai, K-H.; Sun, Z.; Song, L.; Christopher J. Cramer, C. J.; Dorn, H. C.  Enhancing and Predicting the Electron-Nuclear Scalar and Dipolar Interaction in Liquid State 1H and 13C Dynamic Nuclear Polarization, submitted to Chemical Science

Kevin Edgar

Dong, Y.; Edgar, K.J.; Imparting functional variety to cellulose ethers via olefin cross-metathesis. Polymer Chemistry 20156, 3816-3827.

Pereira, J.M.; Mejia-Ariza, R.; Ilevbare, G.A.; McGettigan, H.E.; Sriranganathan, N.; Taylor, L.S.; Davis, R.M.; Edgar, K.J. Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. Molecular Pharmaceutics201310, 4640-4653.

Ilevbare, G.A.; Liu, H.; Edgar, K.J.; Taylor, L.S. Understanding polymer properties important for crystal growth inhibition – impact of chemically diverse polymers on solution crystal growth of ritonavir. Cryst. Growth Des.201212, 3133-3143.

Li, B.; Konecke, S.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. Curcumin Solubility and Chemical Stability are Enhanced by Solid Dispersion in Cellulose Ester Matrices. Carbohydrate Polymers 201398, 1108-1116.

Pawar, S.N.; Edgar, K.J. Chemical modification of alginates in organic solvent systems. Biomacromolecules 201112, 4095-4103.

Felicia A. Etzkorn

Mercedes-Camacho, A. Y.; Mullins, A. B.; Mason, M. D.; Xu, G. G.; Mahoney, B. J.; Wang, X.; Peng, J. W.; Etzkorn, F. A., Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase. Biochemistry 201352 (44), 7707-13.  DOI: 10.1021/bi400700b

Xu, G. G.; Zhang, Y.; Mercedes-Camacho, A. Y.; Etzkorn, F. A., A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry 201150 (44), 9545-50.  DOI: 10.1021/bi201055c

Xu, G. G.; Etzkorn, F. A., Pin1 as an anticancer drug target. Drug News Perspect 2009, 22 (7), 399-407.  DOI: 10.1358/dnp.2009.22.7.1381751

Liu, T.; Kapustin, G. V.; Etzkorn, F., A Novel Histone Deacetylase Inhibitor. Abstracts, 57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 2005, NOV04-011.

Wang, X. J.; Xu, B.; Mullins, A. B.; Neiler, F. K.; Etzkorn, F. A., Conformationally Locked Isostere of PhosphoSer-cis-Pro Inhibits Pin1 23-Fold Better than PhosphoSer-trans-Pro Isostere. J. Am. Chem. Soc. 2004126, 15533-15542.

Joseph Falkinham

Karpin, G. W.; Morris, D. M.; Ngo, M. T.; Merola, J. S.; Falkinham III, J. O. Transition metal diamine complexes with anitmicrobial activity against Staphylococcus aureus and methicillin-recistant S.aureus (MRSA). Med. Chem. Commun., 2015, 6, 1471.

Karpin, G. W.; Merola, J. S.; Falkinham III, J. O. Transition Metal-∝-Amino Acid Compleses with Antibiotic Activity against Mycobacterium spp., aac.asm.org, 201357, 343-3436

Maisuria, B. B.; Actis, M. L.; Hardrict, S. N.; Falkinham III, J. O.; Cole, M. F.; Cihlar, R. L.; Peters, S. M.; Macri, R. V.; Sugandhi, E. W.; Williams, A. A.; Poppe, M. A.; Esker, A. R.; Gandour, R. Comparing micellar, hemolytic, and antibacterial properties of di-and tricarboxyl dendritic amphiphiles, Bioorg. & Med. Chem., 201119, 2918-2926.

Falkinham III, J. O.; Macri, R. V.; Maisuria, B. B.; Actis, M. L.; Sugandhi, E. W.; Williams, A. A.; Snyder, A. V.; Jackson, F. R.; Poppe, M. A.; Chen, L.; Ganesh, K.; Gandour, R. D. Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria,Tuberculosis, 2012, 92, 173-181.

 

Finkielstein, C. V.

Capelluto, D. G. S.; Zhao, X.; Lucas, A.; Lemkul, J. A.; Xiao, S.; Fu, X.; Sun, F.; Bevan, D. R.; Finkielstein, C. V.  Biophysical and Molecular-Dynamics Studies of Phosphatidic Acid Binding by the Dvl-2 DEP Domain Biophysical Journal. 2014, 106, 1101-1111. DOI: 10.1016/j.bpj.2014.01.032

Gotoh, T.; Vila-Caballer, M.; Santos, C. S.; Liu, J.; Yang, J.; Finkielstein, C. V. The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells  Mol.Biol. Cell. 201425, 3081. DOI:10.1091.mbc.E14-05-0993

Gotoh, T.; Vila-Caballer, M.; Liu, J.; Schiffhauer, S.; Finkielstein, C. V.  Association of the circadian factor Period 2 to p53 influences p53’s function in DNA-damage signaling  Mol. Biol. Cell 201426, 359.   DOI: 10.1091/mbc.E14-05-09944

Lucas, A. T.; Fu, X.; Liu, J.; Brannon, M. K.; Yang, J.; Capelluto, D. G. S; Finkielstein.  Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization  PLos ONE. 2014, 9, e112823.  doi:10.1371/journal.pone.0112823

Richard D. Gandour

Savage, A. M.; Li, Y.; Matolyak, L. E.; Doncel, G. F.; Turner, S. R.; Gandour, R. D. Anti-HIV Activities of Precisely Defined, Semirigid, Carboxylated Alternating Copolymers. J. Med. Chem. 201457, 6354–6363.

Robert G. Gourdie

Grek, C. L.; Prasad, G. M.; Viswanathan, V.; Armstrong, D. G.; Gourdie, R. G.; Ghatnekar, G. S. Topical administration of a Connexin43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: A multicenter, randomized trial. Wound Repair Regen. 2015 Feb 19. doi: 10.1111/wrr.12275. [Epub ahead of print]  PMID: 25703647

Ghatnekar, G. S.; Grek, C. L.; Armstrong, D. G., Desai, S. C.; Gourdie, R. G. The effect of a connexin43-based Peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial. J Invest Dermatol. 2015 Jan;135(1):289-98. doi: 10.1038/jid.2014.318. Epub 2014 Jul 29. 32.

Rhett, J. M.; Jourdan, J.; Gourdie, R.G. Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1.  Mol Biol Cell. 2011 May;22(9):1516-28. doi: 10.1091/mbc.E10-06-0548. Epub 2011 Mar 16.PMID: 21411628

Soder, B. L.; Propst, J. T.; Brooks, T. M.; Goodwin, R. L.; Friedman, H. I. Yost, M. J.; Gourdie, R. G. The connexin43 carboxyl-terminal peptide ACT1 modulates the biological response to silicone implants. Plast Reconstr Surg. 2009 May;123(5):1440-51. doi: 10.1097/PRS.0b013e3181a0741d. PMID: 19407614

Ghatnekar, G. S.; O’Quinn, M. P.; Jourdan, L. J.; Gurjarpadhye, A. A.; Draughn, R. L.; Gourdie, R. G. Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding.  Regen Med. 2009 Mar;4(2):205-23. doi: 10.2217/17460751.4.2.205.

A.D. Gross, J.R. Bloomquist (2018) Pharmacology of central octopaminergic and muscarinic pathways in Drosophila melanogaster larvae: Assessing the target potential of GPCRs. Pesticide Biochemistry and Physiology (In Press).

 J. Taylor-Wells, A.D. Gross, J.R. Bloomquist (2018) Examining the mode of action and insecticidal activity of the aphicide flonicamid and its metabolite 4-trifluoromethylnicotinamide for mosquito control. Pesticide Biochemistry and Physiology (In Press).

 J.N. Seiber, J.R. Coats, S.O. Duke, A.D. Gross (2018) Pest management with biopesticides. Frontiers of Agricultural Science and Engineering 5(3): 295-300.

N.R. Larson, P.R. Carlier, A.D. Gross, R.M. Islam, M. Ma, B. Sun, M.M. Totrov, R. Yadav, and J.R. Bloomquist (2017) Toxicology of potassium channel-directed compounds in mosquitoes. NeuroToxicology 60: 214-223.

A.D. Gross, E. J. Norris, L. C. Bartholomay, M. J. Kimber, and J. R. Coats (2017) Essential oils enhance the toxicity of permethrin against Aedes aegypti and Anopheles gambiaeJournal of Medical and Veterinary Entomology, 31(1): 55-62.

 A.D. Gross, N.R. Tabanaca, R. Islam, A. Ali, I.A. Khan, Z.A. Kaplancikli, A. Ozdemir, and J.R. Bloomquist (2017) Toxicity and synergistic activities of novel chalcones against Aedes aegypti (Diptera: Cuilicidae) and Drosophila melanogaster (Diptera: Drosophilidae). Journal of Medical Entomology, 54(2): 382-386.

A.D. Gross, K.B. Temeyer, T.A. Day, A.A. Pérez de León , M.J. Kimber, and J.R. Coats (2017) Plant essential oil terpenoids interacting with the southern cattle tick’s tyramine receptor: A potential biopesticide target. Chemico-Biological Interactions 263(1): 1-6.

D.R. Swale, D.W. Engers, S.R. Bollinger, A. Gross, E. Alfaro Inocente, E. Days, F. Kanga, R.M. Johnson, L. Yang, J.R. Bloomquist, C.R. Hopkins, P.M. Piermarini, J.S. Denton (2016) A small-molecule inhibitor of mosquito inward rectifier potassium channels with resistance-breaking insecticidal activity. Scientific Reports, 6, 36954, doi:10.1038/srep36954.

J.M. Mutunga, Q. Chen, D.M. Wong, P. Lam, J. Li, M.M. Totrov, A.D. Gross, P.R. Carlier, J.R. Bloomquist (2016) Bivalent carbamates as novel control agents of the malaria mosquito, Anopheles gambiaeChimia, 175(1-3): 368-375.

A.D. Gross, K.B. Temeyer, T.A. Day, A.A. Pérez de León, M.J. Kimber, and J.R. Coats (2015) Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus microplusInsect Biochemistry and Molecular Biology, 63: 47-53.

David G. I. Kingston

Kingston, D. G. I.; Snyder, J. P. The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent. Acc. Chem. Res. 2014, 47, 2682–2691. DOI: 10.1021/ar500203h. PMCID: PMC4139185.

Dai, Yumin; Harinantenaina, Liva; Bowman, Jessica D.; Da Fonseca, Isabel Osorio; Brodie, Peggy J.; Goetz, Michael; Cassera, Maria B.; Kingston, David G. I. Isolation of Antiplasmodial Anthraquinones from Kniphofia ensifolia, and Synthesis and Structure-activity Relationships of Related Compounds. Bioorg. Med. Chem. 2014, 22, 269-276. PMCID: PMC3919637

Liva Harinantenaina, Jessica D. Bowman, Peggy J. Brodie, Carla Slebodnick, Martin W. Callmander, Etienne Rakotobe, Richard Randrianaivo, Vincent E. Rasamison, Alexander Gorka, Paul D. Roepe, Maria B. Cassera, and David G. I. Kingston, Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest. J. Nat. Prod., 2013, 76, 388-393. PMCID:PMC3606680.

David G. I. Kingston “Modern Natural Products Drug Discovery and its Relevance to Biodiversity Conservation” J. Nat. Prod. 2011, 74, 496-511. PMCID: PMC3061248

Y. Paik, C. Yang, B. Metaferia, S. Tang, S. Bane, R. Ravindra, N. Shanker, A. A. Alcarez, S. A. Johnson, J. Schaefer, R. D. O’Connor, L. Cegelski, J. P. Snyder, and D. G. I. Kingston. “Rotational-Echo Double-Resonance NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation.” J. Am. Chem. Soc. 2007, 129, 361-370. PMCID: PMC2432525

Michael Klemba

Krai, P, Dalal, S & Klemba, M (2014) Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparumPLoS One9 e89771. PMCID: PMC3934947

Dalal, S, Ragheb, RT, Schubot, FD & Klemba, M (2013) A naturally variable residue in the S1 subsite of M1 family aminopeptidases modulates catalytic properties and promotes functional specialization. J Biol Chem 28826004-12. PMCID: PMC3764805

Denloye, T, Dalal, S & Klemba, M (2012) Characterization of a glycerophosphodiesterase with an unusual tripartite distribution and an important role in the asexual blood stages of Plasmodium falciparumMol Biochem Parasitol 186 29-37.

Harbut, MB, Velmourougane, G, Dalal, S, Reiss, G, Whisstock, JC, Onder, O, Brisson, D, McGowan, S, Klemba, M, Greenbaum, DC (2011) Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases. Proc Natl Acad Sci USA 108 E526-34. PMCID: PMC3161592

Ragheb, D, Dalal, S, Bompiani, KM, Ray, WK & Klemba, M (2011) Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism. J Biol Chem 286 27255-65. PMCID: PMC3149319 

Iuliana Lazar

Tenga, M.J.; Lazar, I.M., “Proteomic Study Reveals a Functional Network of Cancer Markers in the G1-Stage of the Breast Cancer Cell Cycle,“ BMC Cancer 2014, 14, 710 (17 pages). DOI: 10.1186/1471-2407-14-710.

Yang, X.; Lazar, I.M., “XMAn: A Homo sapiens Mutated-Peptide Database for MS Analysis of Cancerous Cell States,” J. Proteome Res. 2014, 13(12), 5486-5495. DOI: 10.1021/pr5004467.

Tenga, M.J.; Lazar, I.M., “Proteomic Snapshot of Breast Cancer Cell Cycle: G1/S Transition Point,” Proteomics 2013, 13(1), 48-60. DOI: 10.1002/pmic.201200188.

Armenta, J.M.; Hoeschele, I.; Lazar, I.M., “Differential Protein Expression Analysis Using Stable Isotope Labeling and PQD Linear Ion Trap MS Technology,” J. Am. Soc. Mass Spectrom., 2009, 20, 1287-1302.DOI:10.1016/j.jasms.2009.02.029.

Yang, X.; Lazar, I.M., “MRM Screening and Biomarker Discovery: A Library of Human Cancer-Specific Peptides,” BMC Cancer 2009, 9(1), 96 (11 pages). DOI: 10.1186/1471-2407-9-96.

Liwu Li

Yuan R, Li L*. Dynamic modulation of innate immunity programming and memory. Science China Life Science. 2016, 59:38-43.

Yuan R, Geng S, Chen K, Diao N, Chu HW, Li L*. Low-grade inflammatory polarization of monocytes impairs wound healing. J Pathology. 2016, In press.

Baker B, Geng S, Chen K, Diao N, Yuan R, Xu X, Dougherty S, Stephenson C, Xiong H, Chu H, Li L*. Alteration of lysosome fusion and low-grade inflammation mediated by super-low dose endotoxinJ Biol Chem. 2015, 290(10):6670-8.

Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, Shen K, Wang J, Liu X, Wang W, Zheng A, Qi C, Si C, He J, Liu K, Lira S, Sikora A, Li L*, Xiong H*. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nature Communications. 2015, 6:6676. * Co-correspondence.

Chen K, Geng S, Yuan R, Diao N, Upchurch Z, Li L*. Super-low dose endotoxin pre-conditioning exacerbates sepsis mortality. eBioMedicine. 2015. 2(4):324-333.

Dongmin Liu

Alkhalidy, H.; Moore, M.; Zhang, Y.; McMillan, R.; Wang, A.; Suh, K-S.; Zhen, W.; Cheng, Z.; Jia, Z.; Hulver, M.; Liu, D. Small molecule kKaempferol promotes insulin sensitivity and preserved pancreatic β-cell mass in middle-aged obese diabetic mice. Journal of Diabetes Research, 2015. (In press).

Liu, L.; Zou, P.; Zheng, L.; Linarelli, L. E.; Amarell, S.; Passaro, A.; Liu, D.; Cheng, Z. Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death & Disease, 2015, 6, e1586.

Jia, Z.; Nallasamy, P.; Liu, D.;  Shah, H.; Chitrakar, R.; Si, H.; McCormick, J.; Zhu, H.; Zhen, W.; Li, Y. Luteolin protects against vascular inflammation in mice and TNF-α-induced monocyte adhesion to primary endothelial cells via suppressing the IκBα/NF-κB pathway. Journal of Nutritional Biochemistry, 2015, 26(3):293-302.

Yang, L.; He, W.; Qu, H.; Jia, C.; Wang, Y.; Liu, D.; Wang, Y.  Phytochemical isoliquiritigenin modulates endothelial cell behavior ex vivo and inhibits neovascularization in vivo. Journal of Alternative & Integrative Medicine, 2015, (In press).

Zhang, W.; Bai, S.; Liu, D.; Cline, M. A.; Gilbert, E. R. Neuropeptide Y promotes adipogenesis in chicken adipose cells in vitro.Comparative Biochemistry and Physiology – Part A: Molecular & Integrative Physiology,2015,181, 62-70.

Fu, Y.; Luo, J.; Jia, Z.; Zhen, W.; Zhou, K.; Gilbert, E.; Liu, D. Baicalein prevents type 2 diabetes via promoting islet β-cell function in obese diabetic mice. International Journal of Endocrinology, 2014, ID 846742: 1-13.

Li, X.; Luo, J.; Anandh Babu, P. V.; Zhang, W.; Gilbert, E.; Cline, M.; McMillan, R.; Hulver, M. W.; Alkhalidy, H.; Zhen, W.; Zhang, H.; Liu D. Dietary supplementation of Chinese ginseng prevents obesity and metabolic syndrome in high-fat diet-fed mice. Journal of Medicinal Foods,2014, 17, 1-11.

Nallasamy, P.; Si, H.; Anandh Babu, P. V.; Fu, Y.; Brooke, E. A.; Shah, H.; Zhen, W.; Zhu, H.; Li, Y.; Liu, D.; Jia, Z. Sulforaphane reduces vascular inflammation in mice and prevent TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway.  Journal of Nutritional Biochemistry, 2014, 25, 824-833.

Timothy Long

Dennis, J. M.; Fahs, G. B.; Moore, R. B.; Turner, S. R.; Long, T. E., Synthesis and characterization of polysulfone-containing poly(butylene terephthalate) segmented block copolymers. Macromolecules 2014, 47, 8171-8177.

Tamami, M.; Zhang, K.; Dixit, N.; Moore, R. B.; Long. T. E., Association of Nucleobase-Containing Ammonium Ionene. Macromolecular Chemistry and Physics 2014, 215, 2337-2344.

Nelson, A. M.; Long, T. E., Synthesis, Properties, and Applications of Ion-Containing Polyurethane Segmented Copolymers. Macromolecular Chemistry and Physics 2014, 215, 2161-2174.

Schultz, A. R.; Jangu, C.; Long, T. E., Thermal and Living Anionic Polymerization of 4-vinylbenzyl piperidine. Polymer Chemistry2014, 5, 6003-6011.

Jangu, C.; Wang, J.-H. H.; Wang, D.; Sharick, S.; Heflin, J. R.; Winey, K. I.; Colby, R. H.; Long, T. E., Well-Defined Imidazolium ABA Triblock Copolymers as Ionic-Liquid-Containing Electroactive Membranes. Macromolecular Chemistry and Physics 2014, 215, 1319-1331.

Buckwalter, D. J.; Hudson, A. G.; Moore, R. B.; Long, T. E., Synthesis and characterization of poly(propylene glycol) polytrioxamide and poly(urea oxamide) segmented copolymers.  Polymer International 2014, 63, 1184-1191.

Schultz, A. R.; Lambert, P. M.; Chartrain, N. A.; Ruohoniemi, D. M.; Zhang, Z.; Jangu, C.;Zhang, M.; Williams, C. B.; Long, T. E. 3D Printing Phosphonium Ionic Liquid  Networks with Mask Projection Microstereolithography. ACS Macro Letters.  2014, 3, 1205-1209.

Long, T. E., Toward Recyclable Thermosets. Science 2014, 344, 706-707.

Zachary Mackey

Valenciano, A. L.; Ramsey, A. C.; Mackey, Z. B., Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression. Cell Cycle 2015, 14 (4), 674-88.  DOI:10.4161/15384101.2014.987611

Sanchez, L. M.; Knudsen, G. M.; Helbig, C.; De Muylder, G.; Mascuch, S. M.; Mackey, Z. B.; Gerwick, L.; Clayton, C.; McKerrow, J. H.; Linington, R. G., Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod 2013, 76 (4), 630-41.  DOI: 10.1021/np300834q

Ndao, M.; Nath-Chowdhury, M.; Sajid, M.; Marcus, V.; Mashiyama, S. T.; Sakanari, J.; Chow, E.; Mackey, Z.; Land, K. M.; Jacobson, M. P.; Kalyanaraman, C.; McKerrow, J. H.; Arrowood, M. J.; Caffrey, C. R., A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother 2013, 57 (12), 6063-73. DOI: 10.1128/AAC.00734-13

Lavrado, J.; Mackey, Z.; Hansell, E.; McKerrow, J. H.; Paulo, A.; Moreira, R., Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett 2012, 22 (19), 6256-60.  DOI: 10.1016/j.bmcl.2012.07.104

Frevert, U.; Movila, A.; Nikolskaia, O. V.; Raper, J.; Mackey, Z. B.; Abdulla, M.; McKerrow, J.; Grab, D. J., Early invasion of brain parenchyma by African trypanosomes. PLoS One 2012, 7 (8), e43913.  DOI:10.1371/journal.pone.0043913

John Matson

Carter, J. M.; Qian, Y.; Foster, J. C.; Matson, J. B. “Peptide-Based Hydrogen Sulfide-Releasing Gels” Chem. Commun. 2015, 51, 13131-13134. doi: 10.1039/c5cc04883d

Foster, J. C.; Matson, J. B. Functionalization of Methacrylate Polymers with Thiooximes: A Robust Post-Polymerization Modification Reaction and a Method for the Preparation of H2S-Releasing Polymers. Macromolecules2014, 47, 5089-5095.

Foster, J. C.; Powell, C. R.; Radzinski, S. C.; Matson, J. B. S-Aroylthiooximes: A Facile Route to Hydrogen Sulfide Releasing Compounds with Structure-Dependent Release Kinetics. Org. Lett. 2014, 16, 1558-1561.

Navon, Y.; Zhou, M.; Matson, J. B.; Bitton R. “Dendritic Elastin-Like Peptides: The Effect of Branching on Thermoresponsiveness” Biomacromolecules 2016, 17, 262-270. doi: 10.1021/acs.biomac.5b01371

Padma Rajagopalan

Jain, G.; Ford, A.; Rajagopalan, P. Opposing Rigidity-Protein Gradients Reverse Fibroblast Durotaxis. ACS Biomaterials Science and Engineering,2015, In Press.

Ford, A. J.; Jain, G.; Rajagopalan, P. Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function. Acta Biomater., 2015 Jun 24.

Vu, L. T.; Jain, G.; Veres, B. D.; Rajagopalan, P. Cell migration on planar and three-dimensional matrices: a hydrogel-based perspective. Tissue Eng Part B Rev. 2015, 21, 67-74.

Vu, L. T.; Less, R. R.; Rajagopalan, P. The promise of organotypic hepatic and gastrointestinal models. Trends Biotechnol. 2014, 32, 406-13.

Webster L. Santos

Patwardhan, N. N.; Morris, E. A.; Kharel, Y.; Raje, M. R.; Gao, M.; Tomsig, J. L.; Lynch, K. R.; Santos, W. L., Structure−Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective Inhibitors. J. Med. Chem. 2015, 58, 1879-1899.

Pablo Sobrado

Guo, S.; Liang, Y.; Murphy, S. F.; Huang, A.; Shen, H.; Kelly, D. F.; Sobrado, P.; Sheng, Z. A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications. Autophagy. 2015 11,560-72.

Bai, Y.; McCoy, J.; Levin, E.; Sobrado, P.; Rajashankar, K.; Fox, B. G.;  Zhang, M. (2015) X-ray Structure of Mammalian Stearoyl-CoA desaturase. NatureIn press.

Binda, C.; Robinson, R.; Martin del Campo, J.S.; Keul, N.; Rodriguez, P.; Robinson, H. H.; Mattevi, A.; Sobrado, P. An unprecedented NADPH domain conformation in Lysine Monooxygenase NbtG provides insights into uncoupling of oxygen consumption from substrate hydroxylation. J. Biol. Chem. 2015,  290, 12676-88.

Badieyan, S.; Bach, R.; Sobrado, P.  Mechanism of N-Hydroxylation Catalyzed by Flavin-dependent Monooxygenases. 2015, J. Org. Chem., 80, 2139-47.

Robel S, Sontheimer H. (2015) Glia as drivers of abnormal neuronal activity. Nat Neurosci 19 (1) 28-33.

Kimbrough, IF, Robel S, Roberson ED, Sontheimer H. (2015) Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease. Brain 138 (Pt 12):3716-3733.

Robert SM, Buckingham SC, Campbell SL, Robel S, Holt KT, Ogunrinu-Babarinde T, Warren PP, White DM, Reid MA, Eschbacher JM, Berens ME, Lahti AC, Nabors LB, Sontheimer H. (2015).SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Science Translational Medicine 7(289).

Robel S, Buckingham SC, Boni JL, Campbell SL, Danbolt NC, Riedmann T, Sutor B, Sontheimer H. (2015). Reactive astrogliosis causes the development of spontaneous seizures. Journal of Neuroscience 35(8), 3330-45.

Sontheimer HW. (2015). Diseases of the Nervous System. Elsevier.

Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H. (2015).GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia 63(1), 23-36.

Seifert S, Sontheimer H. (2014). Bradykinin enhanced the invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration. Journal of Physiology 592(22).

Cuddapah VA, Robel S, Watkins S, Sontheimer H. (2014). A neurocentric perspective on glioma invasion. Nature Reviews in Neuroscience 15(7), 455-65.

Robert SM, Sontheimer H. (2014). Glutamate transporters in the biology of malignant gliomas.Cellular and Molecular Life Sciences 71(10).

Turner KL, Honasoge A, Robert SM, McFerrin MM, Sontheimer H. (2014). A proinvasive role for the Ca(2+)-activated K(+) channel KCa3.1 in malignant glioma. Glia.

Watkins S, Robel S, Kimbrough IK, Robert SM, Ellis-Davies G, Sontheimer H. (2014). Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells. Nature Communications 5.

Abby Whittington

Samavedi, S.; Vaidya, P.; Gaddam, P.; Whittington, A. R.; Goldstein, A. S. Electrospun meshes possessing region-wise differences in fiber orientation, diameter and chemistry for engineering bone-ligament-bone tissues. Biotech & Bioeng, 2014. (Epub ahead of print)

McKeon-Fischer, K.D.; Rossmeisl, J.H.; Whittington, A. R.; Freeman, J. W. In Vivo Skeletal Muscle Biocompatibility of Composite, Coaxial Electrospun, and Microfibrous ScaffoldsTissue Eng A, 2014, 20, 1961 – 1970.