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Screening Lab

Photo of Mike Klemba

Photo of Nancy Vogelaar

Welcome to VTCDDSL!

The Virginia Tech Center for Drug Discovery Screening Laboratory (VTCDDSL) assists researchers to develop and carry out high-throughput assays.  The laboratory is BSL2 certified and can do both cell-based and enzyme-based screening assays. The facility is available to the Virginia Tech community and users have access to over 40,000 chemical compounds.

Purchase of the equipment for the VTCDDSL was made possible by funds from the Fralin Life Sciences Institute.

Facility instruments are compatible with 96-well and 384-well microplates. Other microplate types may be used on select instruments.

Biotek Multiflo Dispenser with Biostak unit (1-3,000 ul)
Tiertek Multidrop with integrated stacker (96-well only; 5-395 ul; mobile)
Agilent Bravo Liquid Dispensing Platform w/ST96 head (0.3-70 ul; 96 individual dispensing channels)
Biotek Plate Washer (compatible with Biostak unit) - For washing loosely adherent cells and ELISA processing
Photo of V&P Scientific 48-pin replicator tool (VP 408H)
V&P Scientific 48-pin replicator tool (VP 408H) - For manual use with agar or microplates; 2 ul liquid-to-solid transfer/0.25 ul liquid-to-solid transfer
Heidolph Orbital Shaker (27-plate capacity)
Tabletop Centrifuge w/sealed microplate rotors (4 plate capacity)
Molecular Devices M5 Multimode Spectrophotometer w/Stacker and Barcode Reader (96-, 384-well, and others; top-read/bottom-read; absorbance, luminescence, fluorescence, fluorescence polarization, time-resolved fluorescence)
Waters Acquity H-class UPLC (P. Sobrado's, housed at VTCDDSL) - Analytical separations

We have a number of compound libraries available to researchers including a library of FDA-approved drugs, a natural-products library, a unique transition-metal complex library developed by Dr. Joe Merola, a brominated fragment library, a kinase-targeted library, as well as other libraries designed to maximize structural and chemical diversity.  (See table below).  Please note that commercial compound collections change over time as compounds are added or removed.  For specific information about our libraries, please contact the screening lab.


Library Description                                 # cmpds   

Microsource Spectrum Library  

Wide range of biological activities and structural diversity  


Analyticon Discovery Academic NATx Library
“Compounds based on bioactive natural products (70 scaffolds) further modified with both natural and unusual pharmacophore groups


Chembridge Library

Custom selection from the Chembridge DiverSet


TargetMol Natural Products Library

Natural products with known bioactivity and good availability 


Otava Brominated- Fragment Library

For fragment-based drug design (bromine incorporation facilitates identification of binding sites by x-ray crystallography)  




# cmpds     

ApexBio DiscoveryProbeTM Clinical and FDA-Approved Library 

Approved drugs and compounds in clinical trials


ApexBio DiscoveryProbeTM Anti-Infection

Potent, selective and cell-permeable compounds that inhibit or activate target molecules involved in the infection process


Selleckchem Antibiotic

Structurally diverse, medicinally active, and cell permeable


Selleckchem Kinase Library

Structurally diverse inhibitors for kinases including RTKs, PI3K, Aurora Kinase, CDK, and MEK (most inhibitors competitive with ATP)


MedChemExpress Kinase Inhibitor Library

Inhibitors and regulators targeting diverse protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc) , lipid kinases (PI3K, PI4K, SK, etc), and carbohydrate kinases.


MedChemExpress Lipid Metabolism Library

Compound targets relevant to lipid metabolism include ATGL, MAGL, FAAH, acetyl-CoA carboxylase, FASN, and others.


Merola Tailored Transition-Metal Library (TTMC)

Numerous compounds have demonstrated anti-mycobacterial activity and activity against S. aureus including strains of MRSA.  Custom variants easily synthesized.



Contact the Screening Lab!

Dr. Michael Klemba

VTCDDSL Director
Department of Biochemistry
(540) 231-5729
The VT Center for Drug Discovery's Screening lab is located in Engel Hall, Room 301. 
Manager: Dr. Nancy Vogelaar, (540) 231-3525,